薑黃素 (Curcumin)是咖哩中的薑黃的黃色素，在動物實驗中被證實可以預防心臟肥大，心臟肥大會增加心臟病的風險。

 Histone acetylation 在心臟肥大中扮演關鍵的地位。薑黃素 (Curcumin) 可以抑制 Histone acetylation，也抑制了心臟肥大。研究人員以老鼠做實驗，證實薑黃素 (Curcumin) 可以預防且逆轉心臟肥大。薑黃素 (Curcumin) 也減少發炎及纖維化。

另外一篇老鼠的研究中，薑黃素對高血壓的心臟病及手術導致的心肌梗塞，有防止心臟衰竭的效果。

 

Hong-Liang Li, Chen Liu, Geoffrey de Couto, Maral Ouzounian, Mei Sun, Ai-Bing Wang, Yue Huang, Cheng-Wei He, Yu Shi, Xin Chen, Mai P. Nghiem, Youan Liu, Manyin Chen, Fayez Dawood, Masahiro Fukuoka, Yuichiro Maekawa, Liyong Zhang, Andrew Leask, Asish K. Ghosh, Lorrie A. Kirshenbaum, Peter P. Liu. Curcumin prevents and reverses murine cardiac hypertrophy. Journal of Clinical Investigation.  February 21, 2008. Published online ahead of print.

Morimoto T, Sunagawa Y, Kawamura T, Takaya T, Wada H,  Nagasawa A, Komeda M, Fujita M, Shimatsu A, Kita T, Hasegawa K.

The dietary compound curcumin inhibits p300 histone acetyltransferase activity and prevents heart failure in rats. Journal of Clinical Investigation.  February 21, 2008. Published online ahead of print.